As a portly woman plodded ahead of him on the sidewalk, the obese mayor of America's fattest and unhealthiest city explained why health is not a big local issue.

What was left of Dan Sivia's ankle simply didn't work. He limped through his 30s by sheer force of will, one foot almost completely immobile from repeated broken bones and surgeries. Then a doctor offered his last hope: An ankle replacement. A what? Sivia knew about hip, knee, even shoulder replacements. But ankles?

Dr. Adrian Kantrowitz, a cardiac surgeon who performed the nation's first human heart transplant and who also developed lifesaving medical implants, has died. He was 90. Kantrowitz died Friday in Ann Arbor of complications from heart failure, said his wife, Jean Kantrowitz.

Florence Wald, a former Yale nursing dean whose interest in compassionate care led her to launch the first U.S. hospice program, has died. She was 91.